Promoting patient followup treatment with intra-detrusor onabotulinumtoxinA

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OnabotulinumtoxinA improves urodynamic outcomes in patients with neurogenic detrusor overactivity.

AIMS To evaluate the effect of onabotulinumtoxinA on urodynamic outcomes in patients with urinary incontinence (UI) due to neurogenic detrusor overactivity (NDO). METHODS Results from two pivotal Phase III trials (n = 691) were pooled. MS or SCI patients with NDO, received intradetrusor onabotulinumtoxinA 200 U (n = 227), 300 U (n = 223), or placebo (n = 241). Change from baseline in UI episo...

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300 IU vs. 200 IU of OnabotulinumtoxinA for detrusor overactivity

Botulinum toxin is probably the newest addition in the treatment armamentarium for overactive bladder , but, despite its late FDA approval, a significant experience exists in several centers around the world with this type of treatment. Because of its experimental status, the treatment with botulinum toxin is still lacking the much needed standardization, allowing for a great variety when it co...

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Efficacy and Adverse Events Associated With Use of OnabotulinumtoxinA for Treatment of Neurogenic Detrusor Overactivity: A Meta-Analysis

PURPOSE OnabotulinumtoxinA is used widely for the treatment of neurogenic detrusor overactivity. We conducted a systematic review and meta-analysis to assess its efficacy and safety for neurogenic detrusor overactivity treatment. METHODS A systematic literature review was performed to identify all published randomized double-blind, placebo-controlled trials of onabotulinumtoxinA for neurogeni...

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Efficacy and Safety of Intravesical OnabotulinumtoxinA Injection in Patients with Detrusor Hyperactivity and Impaired Contractility.

We investigated the efficacy and safety of intravesical onabotulinumtoxinA injection in patients with detrusor hyperactivity and impaired contractility (DHIC). Twenty-one patients with urodynamically proven DHIC and 21 age-matched patients with overactive bladder (OAB) with urodynamic detrusor overactivity were treated with intravesical injections of 100 U of onabotulinumtoxinA. The overactive ...

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Patient treatment preferences for symptomatic refractory urodynamic idiopathic detrusor overactivity

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ژورنال

عنوان ژورنال: Canadian Urological Association Journal

سال: 2021

ISSN: 1920-1214,1911-6470

DOI: 10.5489/cuaj.6983